Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 7/20 | 0.47 |
| ▸ | MAOB | P27338 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29417804 | 0.87 | LTA4H (0.61) | SMN1; SMN2LMNAMAPK1HTTLTA4H | |
| SCHEMBL1283353 | 0.87 | LTA4H (0.61) | SMN1; SMN2LMNAMAPK1HTTLTA4H | |
| SCHEMBL29417616 | 0.86 | BACE1 (0.62) | SMN1; SMN2LMNAMAPK1HTTLTA4H | |
| SCHEMBL4965868 | 0.86 | BACE1 (0.62) | SMN1; SMN2LMNAMAPK1HTTLTA4H | |
| SCHEMBL29417693 | 0.85 | KDM4E (0.62) | SMN1; SMN2LMNAMAPK1HTTLTA4H | |
| SCHEMBL210600 | 0.85 | KDM4E (0.62) | SMN1; SMN2LMNAMAPK1HTTLTA4H | |
| Hydrochloric Acid SCHEMBL5692360 | 0.82 | LTA4H (0.50) | SMN1; SMN2LMNALTA4HMAOAMAOB | |
| SCHEMBL1039170 | 0.80 | KDM4E (0.64) | SMN1; SMN2KDM4EALDH1A1TSHRKMT2A | |
| SCHEMBL17688069 | 0.79 | BACE1 (0.71) | SMN1; SMN2LTA4HKDM4EALDH1A1BACE1 | |
| Hydrochloric Acid SCHEMBL2425484 | 0.78 | KDM4E (0.63) | SMN1; SMN2KDM4EALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996028448-A1 | 6-ARYL PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-09-19 | — | — | WO | disclosed |