Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245195 | 0.88 | DPP7 (0.55) | MAPK14KDM4EMEN1KMT2ABCHE | |
| SCHEMBL5947704 | 0.84 | KDM4E (0.69) | MAPK14KDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5227682 | 0.83 | DPP7 (0.57) | KDM4EMEN1KMT2ADPP7SCN8A | |
| SCHEMBL4239980 | 0.83 | DPP7 (0.59) | KDM4EALDH1A1MEN1KMT2ABCHE | |
| SCHEMBL7756966 | 0.81 | KDM4E (0.70) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL7243973 | 0.80 | MAOB (0.57) | KDM4EMEN1KMT2ADPP7SCN8A | |
| SCHEMBL8809177 | 0.80 | ALDH1A1 (0.79) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL9079843 | 0.79 | KDM4E (0.68) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL8497858 | 0.79 | KDM4E (0.67) | MAPK14KDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5947469 | 0.78 | KDM4E (0.62) | MAPK14KDM4EALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |