Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942967 | 0.91 | SIGMAR1 (0.35) | SIGMAR1KMT2AMEN1KDM4ECCR3 | |
| SCHEMBL6944091 | 0.91 | CCR3 (0.33) | SIGMAR1KMT2AMEN1KDM4ECCR3 | |
| SCHEMBL9081846 | 0.90 | SIGMAR1 (0.42) | SIGMAR1KMT2AMEN1KDM4EALOX15 | |
| SCHEMBL6943073 | 0.90 | CCR3 (0.37) | KMT2AMEN1KDM4ECCR3ALDH1A1 | |
| SCHEMBL9284924 | 0.90 | SIGMAR1 (0.41) | SIGMAR1KMT2AMEN1KDM4EALOX15 | |
| SCHEMBL6154290 | 0.87 | CCR3 (0.35) | KMT2AMEN1KDM4ECCR3ALDH1A1 | |
| SCHEMBL6946261 | 0.87 | POLB (0.35) | SIGMAR1KMT2AMEN1KDM4ECCR3 | |
| SCHEMBL6154565 | 0.87 | CCR3 (0.34) | KMT2AMEN1KDM4ECCR3ALDH1A1 | |
| SCHEMBL6152354 | 0.86 | CCR3 (0.33) | KDM4ECCR3ALDH1A1ORAI1 | |
| SCHEMBL6153058 | 0.86 | CCR3 (0.33) | KDM4ECCR3ALDH1A1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996006083-A1 | 2-(PIPERAZINYL-1-CARBONYLMETHYL)-1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1996-02-29 | — | — | WO | disclosed |