Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.54 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.36 |
| ▸ | GABRP | O00591 | 3/20 | 0.35 |
| ▸ | GABRD | O14764 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.35 |
| ▸ | GABRE | P78334 | 3/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14029046 | 0.74 | TOP2A (0.78) | TOP2ATOP2BNPC1RAB9ALMNA | |
| SCHEMBL9029007 | 0.72 | TOP2A (0.49) | TOP2ATOP2BAAK1NPC1RAB9A | |
| SCHEMBL9112379 | 0.72 | TOP2A (0.49) | TOP2ATOP2BAAK1NPC1RAB9A | |
| SCHEMBL9028183 | 0.72 | TOP2A (0.49) | TOP2ATOP2BAAK1NPC1RAB9A | |
| SCHEMBL9112632 | 0.72 | TOP2A (0.49) | TOP2ATOP2BAAK1NPC1RAB9A | |
| SCHEMBL549309 | 0.71 | TOP2A (1.00) | TOP2ATOP2BNPC1RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL7724236 | 0.70 | TOP2A (1.00) | TOP2ATOP2BNPC1RAB9ALMNA | |
| SCHEMBL9113764 | 0.70 | TOP2A (0.58) | TOP2ATOP2BNPC1RAB9ALMNA | |
| SCHEMBL9114197 | 0.70 | TOP2A (0.58) | TOP2ATOP2BNPC1RAB9ALMNA | |
| SCHEMBL9081115 | 0.69 | PRMT1 (0.54) | TOP2ATOP2BAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996028443-A1 | THERAPEUTIC BENZOXAZOLES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-09-19 | — | — | WO | disclosed |