Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.74 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.54 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695758 | 0.90 | ADRA1D (0.73) | ADRA1DADRA1AADRA1BGRIN2BHTR2A | |
| SCHEMBL9082550 | 0.89 | ADRA1D (0.71) | ADRA1DADRA1AADRA1BGRIN2BHTR2A | |
| SCHEMBL9085175 | 0.89 | ADRA1D (0.71) | ADRA1DADRA1AADRA1BGRIN2BHTR2A | |
| SCHEMBL9082586 | 0.89 | ADRA1D (0.71) | ADRA1DADRA1AADRA1BGRIN2BHTR2A | |
| SCHEMBL9081216 | 0.86 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BGRIN2BHTR2A | |
| SCHEMBL9082688 | 0.85 | ADRA1D (0.63) | ADRA1DADRA1AADRA1BGRIN2BHTR2A | |
| SCHEMBL9084496 | 0.85 | ADRA1D (0.60) | ADRA1DADRA1AADRA1BGRIN2BHTR2A | |
| SCHEMBL7034334 | 0.85 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BGRIN2BHTR1D | |
| SCHEMBL12422869 | 0.84 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BGRIN2BSIGMAR1 | |
| SCHEMBL9288534 | 0.83 | ADRA1D (0.78) | ADRA1DADRA1AADRA1BGRIN2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508306-A | USED FOR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA, LOWERING INTRAOCULAR PRESSURE AND INHIBITING CHOLESTEROL SYNTHESIS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |