Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | RAB9A | P51151 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330348 | 0.84 | ELANE (0.50) | ELANENPC1RAB9ASMN1; SMN2MTNR1A | |
| SCHEMBL7329575 | 0.81 | ELANE (0.38) | ELANENPC1RAB9ASMN1; SMN2MTNR1A | |
| SCHEMBL7423743 | 0.80 | GFER (0.38) | ELANENPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7421692 | 0.76 | ELANE (0.36) | ELANE | |
| SCHEMBL7332491 | 0.74 | MTNR1A (0.35) | NPC1RAB9ASMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL7331991 | 0.72 | ELANE (0.38) | ELANENPC1RAB9ASMN1; SMN2MTNR1A | |
| SCHEMBL7335115 | 0.66 | ELANE (0.53) | ELANESMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7329786 | 0.65 | ELANE (0.54) | ELANENPC1RAB9AALDH1A1POLB | |
| SCHEMBL7328422 | 0.63 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7330116 | 0.63 | KMT2A (0.35) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556909-A | PROTEOLYTIC ENZYME INHIBITOR, TREATMENT OF DEGENERATIVE DISEASES, SUCH AS EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI WINTHROP INC. (US) | 1996-09-17 | — | — | US | disclosed |