Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 13/20 | 0.82 |
| ▸ | PRKACG | P22612 | 13/20 | 0.82 |
| ▸ | PRKACB | P22694 | 13/20 | 0.82 |
| ▸ | CDK4 | P11802 | 4/20 | 0.82 |
| ▸ | CCND1 | P24385 | 4/20 | 0.82 |
| ▸ | PRKCA | P17252 | 4/20 | 0.82 |
| ▸ | PRKCB | P05771 | 3/20 | 0.82 |
| ▸ | PRKCH | P24723 | 3/20 | 0.82 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.82 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.82 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.82 |
| ▸ | PIM1 | P11309 | 2/20 | 0.82 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.82 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.82 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.82 |
| ▸ | CDK2 | P24941 | 2/20 | 0.82 |
| ▸ | GSK3B | P49841 | 2/20 | 0.82 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.82 |
| ▸ | CDK1 | P06493 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9084351 | 0.94 | PRKACA (0.72) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9084087 | 0.94 | PRKACA (0.81) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9083061 | 0.92 | PRKACA (0.81) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9087576 | 0.91 | PRKACA (0.77) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9086987 | 0.91 | PRKACA (0.77) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9086320 | 0.91 | PRKACA (0.82) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| Gf-109203 SCHEMBL29353725 | 0.90 | PRKACA (1.00) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| Gf-109203 SCHEMBL338086 | 0.90 | PRKACA (1.00) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9087353 | 0.90 | PRKACA (0.81) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9088590 | 0.90 | PRKACA (0.81) | PRKACAPRKACGPRKACBCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516915-A | Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1996-05-14 | — | — | US | disclosed |
| US-5380746-A | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1995-01-10 | — | — | US | disclosed |
| EP-0397060-A2 | Maleinimide derivatives and their use as medicines | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-11-14 | — | — | EP | disclosed |