Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 6/20 | 0.56 |
| ▸ | KDR | P35968 | 10/20 | 0.52 |
| ▸ | KIT | P10721 | 9/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 9/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90828 | 0.92 | ACVRL1 (0.55) | ACVRL1KDRKITTEKMERTK | |
| SCHEMBL90886 | 0.91 | ACVRL1 (0.56) | ACVRL1KDRKITTEKMERTK | |
| SCHEMBL90884 | 0.91 | ACVRL1 (0.55) | ACVRL1KDRKITTEKMERTK | |
| SCHEMBL58935 | 0.91 | ACVRL1 (0.57) | ACVRL1KDRKITTEKMERTK | |
| SCHEMBL57964 | 0.91 | ACVRL1 (0.60) | ACVRL1KDRKITTEKMERTK | |
| SCHEMBL65790 | 0.90 | ACVRL1 (0.63) | ACVRL1KDRKITTEKMERTK | |
| Hydrochloric Acid SCHEMBL58421 | 0.90 | ACVRL1 (0.62) | ACVRL1KDRKITTEKMERTK | |
| SCHEMBL10278863 | 0.89 | ACVRL1 (0.53) | ACVRL1TEKMERTKFLT3ERN1 | |
| SCHEMBL10278467 | 0.89 | ACVRL1 (0.57) | ACVRL1KDRKITTEKMERTK | |
| SCHEMBL90880 | 0.87 | ACVRL1 (0.50) | ACVRL1MERTKFLT3ERN1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129379-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-06 | — | — | US | disclosed |
| US-20100179125-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179125-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | CDK4, CDKL4, MKI67 | ACVRL1 941/4885KDR 41/4885KIT 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.