Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 3/20 | 0.59 |
| ▸ | KDR | P35968 | 16/20 | 0.51 |
| ▸ | FLT3 | P36888 | 9/20 | 0.51 |
| ▸ | KIT | P10721 | 8/20 | 0.51 |
| ▸ | FLT1 | P17948 | 7/20 | 0.49 |
| ▸ | FLT4 | P35916 | 7/20 | 0.49 |
| ▸ | CSF1R | P07333 | 6/20 | 0.49 |
| ▸ | LCK | P06239 | 6/20 | 0.49 |
| ▸ | BLK | P51451 | 6/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | LYN | P07948 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | AXL | P30530 | 4/20 | 0.49 |
| ▸ | FRK | P42685 | 4/20 | 0.49 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.49 |
| ▸ | CSNK1G1 | Q9HCP0 | 4/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90935 | 0.91 | KDR (0.51) | ACVRL1KDRFLT3KITFLT1 | |
| SCHEMBL58124 | 0.91 | KDR (0.62) | ACVRL1KDRFLT3KITFLT1 | |
| SCHEMBL58142 | 0.90 | ACVRL1 (0.57) | ACVRL1KDRFLT3KITFLT1 | |
| SCHEMBL90924 | 0.90 | KDR (0.49) | ACVRL1KDRFLT3KITFLT1 | |
| SCHEMBL57826 | 0.88 | KDR (0.59) | ACVRL1KDRFLT3KITFLT1 | |
| SCHEMBL90824 | 0.88 | KDR (0.48) | ACVRL1KDRFLT3KITFLT1 | |
| SCHEMBL59065 | 0.85 | ACVRL1 (0.47) | ACVRL1KDRFLT3KITFRK | |
| SCHEMBL90826 | 0.83 | ACVRL1 (0.49) | ACVRL1KDRFLT3KITFLT1 | |
| SCHEMBL59210 | 0.83 | ACVRL1 (0.59) | ACVRL1KDRFLT3KITFLT1 | |
| SCHEMBL58915 | 0.83 | ACVRL1 (0.62) | ACVRL1KDRFLT3KITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129379-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-06 | — | — | US | disclosed |
| US-20100179125-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179125-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | CDK4, CDKL4, MKI67 | ACVRL1 941/4885KDR 41/4885FLT3 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.