Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1311669 | 0.89 | PIK3CA (0.82) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1309226 | 0.88 | PIK3CA (0.64) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL908530 | 0.87 | PIK3CA (0.62) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1310887 | 0.85 | PIK3CA (0.60) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1310883 | 0.85 | PIK3CA (0.60) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL910378 | 0.84 | PIK3CA (0.66) | PIK3CAMTORPIK3R1 | |
| SCHEMBL1309999 | 0.82 | PIK3CA (0.63) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL908397 | 0.82 | PIK3CA (0.72) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15558168 | 0.81 | PIK3CA (0.58) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL18193166 | 0.81 | PIK3CA (1.00) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014005182-A1 | PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS | MONASH UNIVERSITY (AU) | 2014-01-09 | — | — | WO | disclosed |
| EP-2276750-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | Auckland Uniservices Limited (NZ) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009120094-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-10-01 | — | — | WO | disclosed |