Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 2/20 | 0.42 |
| ▸ | MME | P08473 | 3/20 | 0.37 |
| ▸ | ACE | P12821 | 3/20 | 0.37 |
| ▸ | F7 | P08709 | 4/20 | 0.35 |
| ▸ | F3 | P13726 | 4/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9087316 | 0.89 | GHSR (0.58) | GHSRAGTR1XIAPMMEACE | |
| SCHEMBL9024591 | 0.88 | GHSR (0.46) | GHSRAGTR1XIAPMMEACE | |
| SCHEMBL9025080 | 0.88 | GHSR (0.46) | GHSRAGTR1XIAPMMEACE | |
| SCHEMBL9089642 | 0.87 | GHSR (0.60) | GHSRAGTR1XIAP | |
| SCHEMBL9089069 | 0.85 | GHSR (0.43) | GHSRAGTR1XIAPMMEACE | |
| SCHEMBL9089962 | 0.85 | GHSR (0.48) | GHSRAGTR1XIAPMMEACE | |
| SCHEMBL9218242 | 0.84 | XIAP (0.45) | GHSRAGTR1XIAPMMEACE | |
| SCHEMBL7795570 | 0.83 | GHSR (0.46) | GHSRAGTR1XIAPMMEACE | |
| SCHEMBL7794433 | 0.83 | XIAP (0.47) | GHSRAGTR1XIAPMMEACE | |
| SCHEMBL7791803 | 0.83 | XIAP (0.44) | GHSRAGTR1XIAPMMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665748-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | — | 1995-08-23 | — | — | EP | claimed |
| EP-0665748-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-08-09 | — | — | EP | claimed |
| WO-1994007486-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | claimed |
| US-5583130-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1996-12-10 | — | — | US | disclosed |
| WO-1994007486-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | disclosed |