Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28212011 | 0.98 | EPHX1 (0.39) | EPHX1LMNAPOLBSMN1; SMN2KDM4E | |
| SCHEMBL15614667 | 0.83 | EPHX1 (0.39) | EPHX1POLBSMN1; SMN2TET2TSHR | |
| SCHEMBL30631642 | 0.82 | SMN1; SMN2 (0.36) | LMNAPOLBSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL30130653 | 0.81 | EPHX1 (0.38) | EPHX1TET2TSHR | |
| SCHEMBL4202727 | 0.79 | TDP1 (0.48) | EPHX1LMNAPOLBKDM4EGAA | |
| SCHEMBL24698537 | 0.79 | EPHX1 (0.41) | EPHX1LMNAPOLBGAATET2 | |
| SCHEMBL16236145 | 0.79 | LMNA (0.36) | LMNAPOLBSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL9089162 | 0.78 | SMN1; SMN2 (0.34) | LMNAPOLBSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL21149310 | 0.78 | TSHR (0.36) | LMNAPOLBSMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL4730960 | 0.77 | EPHX1 (0.41) | EPHX1SMN1; SMN2GAATET2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108690016-A | Pyrazolo-pyridines and application thereof | 广东东阳光药业有限公司 | 2018-10-23 | — | — | CN | claimed |
| US-5494666-A | BETA-LACTAMASE INHIBITORS, ANTIBACTERIALS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | claimed |
| WO-2023116884-A1 | CDK2 INHIBITORS AND USE THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2023-06-29 | — | — | WO | disclosed |
| CN-108690016-B | Pyrazolopyridines and uses thereof | 广东东阳光药业有限公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-108690016-A | Pyrazolo-pyridines and application thereof | 广东东阳光药业有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-104395313-B | Azabicyclo replacing and application thereof | 拜耳知识产权有限责任公司 | 2017-03-08 | — | — | CN | disclosed |
| EP-2895482-B1 | HIV PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015134366-A1 | HIV PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-09-11 | — | — | WO | disclosed |
| WO-2014043019-A1 | HIV PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-03-20 | — | — | WO | disclosed |
| US-5494666-A | BETA-LACTAMASE INHIBITORS, ANTIBACTERIALS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| US-5464617-A | 1H-2,6a-diazacyclobut(cd)indene-6-carboxylic acid derivatives, antibiotics | HOFFMANN-LA ROCHE INC. (US) | 1995-11-07 | — | — | US | disclosed |