Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28270972 | 0.82 | ALDH1A1 (0.51) | KDM4EALDH1A1NSD2CA1CA2 | |
| Hydrochloric Acid SCHEMBL28088858 | 0.80 | ALDH1A1 (0.50) | KDM4EALDH1A1NSD2CA1CA2 | |
| SCHEMBL28203165 | 0.72 | ALDH1A1 (0.50) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL8847160 | 0.70 | ALDH1A1 (0.41) | MAPTSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL8434248 | 0.69 | UHRF1 (0.46) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL27757723 | 0.68 | MAPT (0.52) | MAPTSMN1; SMN2KDM4EALDH1A1PSEN1 | |
| SCHEMBL1385348 | 0.68 | ALDH1A1 (0.41) | MAPTSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL3644768 | 0.68 | ALDH1A1 (0.42) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL2403194 | 0.67 | MAPT (1.00) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| Fluoride SCHEMBL27839384 | 0.67 | UHRF1 (0.45) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655065-B1 | 27-HYDROXYRAPAMYCIN AND DERIVATIVES THEREOF | AMERICAN HOME PROD (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0655065-A1 | 27-HYDROXYRAPAMYCIN AND DERIVATIVES THEREOF. | AMERICAN HOME PROD (US) | 1995-05-31 | — | — | EP | disclosed |
| US-5302600-A | Inducing immunosuppression; antiinflammatory agents, antifungal, antitumor and antiproliferative agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |
| WO-1994004540-A1 | 27-HYDROXYRAPAMYCIN AND DERIVATIVES THEREOF | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-03-03 | — | — | WO | disclosed |
| US-5260299-A | Treats transplantation rejection, host versus graft disease and diseases of inflammation by administering in mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| US-5256790-A | Antibiotic | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |
| US-5177203-A | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-01-05 | — | — | US | disclosed |