Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.61 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 4/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9090942 | 0.90 | AGTR1 (0.71) | AGTR1AGTR2PTPN1PLK1PLK3 | |
| SCHEMBL9090023 | 0.87 | AGTR1 (0.64) | AGTR1AGTR2PTPN1PLK1PLK3 | |
| SCHEMBL9090103 | 0.87 | AGTR1 (0.57) | AGTR1AGTR2PLK1PLK3ALDH1A1 | |
| SCHEMBL7049608 | 0.85 | AGTR1 (0.83) | AGTR1AGTR2PTPN1PLK1PLK3 | |
| SCHEMBL9091315 | 0.85 | AGTR1 (0.55) | AGTR1AGTR2ALDH1A1L3MBTL1TP53 | |
| SCHEMBL9090892 | 0.83 | AGTR1 (0.66) | AGTR1AGTR2PTPN1PLK1PLK3 | |
| SCHEMBL9090900 | 0.82 | AGTR1 (0.67) | AGTR1AGTR2ALDH1A1GAATP53 | |
| SCHEMBL9090133 | 0.81 | AGTR1 (0.61) | AGTR1AGTR2PTPN1ALDH1A1MAPT | |
| SCHEMBL9091478 | 0.81 | AGTR1 (0.54) | AGTR1AGTR2PTPN1PLK1ALDH1A1 | |
| SCHEMBL9089027 | 0.81 | AGTR1 (0.56) | AGTR1AGTR2ALDH1A1L3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571925-A | HORMONES INHIBITORS FOR HYPOTENSIVE AGENTS | ELI LILLY AND COMPANY (US) | 1996-11-05 | — | — | US | disclosed |
| US-5563278-A | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0438869-B1 | Improvements in and relating to angiotensin II antagonists | LILLY CO ELI (US) | 1994-12-14 | — | — | EP | disclosed |
| US-5312936-A | Hypotensive agents | ELI LILLY AND COMPANY (US) | 1994-05-17 | — | — | US | disclosed |
| US-5073566-A | Hypotensive agents | ELI LILLY AND COMPANY (US) | 1991-12-17 | — | — | US | disclosed |