Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.38 |
| ▸ | PTGFR | P43088 | 4/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9091571 | 0.85 | PTGFR (0.41) | HDAC1HDAC2NR5A2PTGFRPTGER1 | |
| SCHEMBL9089528 | 0.85 | ALDH1A1 (0.40) | MAPTRXFP1HDAC3HDAC4HDAC1 | |
| SCHEMBL9090656 | 0.83 | NR5A2 (0.33) | MAPTNR5A2FFAR4LMNATSHR | |
| SCHEMBL10976736 | 0.81 | NR5A2 (0.35) | NR5A2PTGER2FFAR4 | |
| SCHEMBL9087930 | 0.81 | NR5A2 (0.35) | NR5A2PTGER2FFAR4 | |
| SCHEMBL9086567 | 0.80 | NR5A2 (0.33) | NR5A2 | |
| SCHEMBL9091252 | 0.80 | NR5A2 (0.33) | NR5A2 | |
| SCHEMBL9089666 | 0.80 | NR5A2 (0.37) | NR5A2 | |
| SCHEMBL9090798 | 0.80 | NR5A2 (0.34) | NR5A2PTGFRPTGER1PTGER2PTGER3 | |
| SCHEMBL9089061 | 0.80 | NR5A2 (0.35) | NR5A2PTGER2EPHX1PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0136779-B1 | NEW CARBACYCLIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1988-09-14 | — | — | EP | claimed |
| EP-0136779-A1 | New carbacyclin derivatives, processes for their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1985-04-10 | — | — | EP | claimed |
| US-5489613-A | TREATING THROMBOSIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-06 | — | — | US | disclosed |
| US-5405870-A | Platelet-aggregation inhibitors; useful in treatment of thrombosis | SANKYO COMPANY, LIMITED (JP) | 1995-04-11 | — | — | US | disclosed |
| EP-0136779-A1 | New carbacyclin derivatives, processes for their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1985-04-10 | — | — | EP | disclosed |