Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30576844 | 0.80 | KMT2A (0.48) | KMT2AHTTEPHX2POLB | |
| SCHEMBL14282244 | 0.78 | KMT2A (0.50) | KMT2AHTTALDH1A1EPHX2HSD11B1 | |
| SCHEMBL7804748 | 0.78 | KMT2A (0.50) | KMT2AHTTALDH1A1EPHX2POLB | |
| SCHEMBL14941550 | 0.76 | KMT2A (0.48) | KMT2AHTTALDH1A1EPHX2HSD11B1 | |
| SCHEMBL5522397 | 0.76 | KMT2A (0.48) | KMT2AHTTALDH1A1EPHX2POLB | |
| SCHEMBL47336 | 0.76 | KMT2A (0.48) | KMT2AHTTALDH1A1EPHX2POLB | |
| SCHEMBL965286 | 0.76 | KMT2A (0.82) | KMT2AHTTALDH1A1EPHX2POLB | |
| SCHEMBL1446126 | 0.74 | EPHX2 (0.50) | KMT2AHTTALDH1A1EPHX2MAPT | |
| SCHEMBL1446123 | 0.74 | EPHX2 (0.50) | KMT2AHTTALDH1A1EPHX2ATM | |
| SCHEMBL17273858 | 0.74 | KMT2A (0.78) | KMT2AHTTALDH1A1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506262-A | ANTICHOLESTEROL AGENTS, FUNGICIDES, ANTICARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1996-04-09 | — | — | US | disclosed |
| WO-1992020336-A2 | NOVEL CHOLESTEROL LOWERING COMPOUNDS | MERCK & CO., INC. (US) | 1992-11-26 | — | — | WO | disclosed |
| EP-0512865-A2 | Novel cholesterol lowering compounds | MERCK & CO. INC. (US) | 1992-11-11 | — | — | EP | disclosed |