Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.81 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.81 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.75 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.75 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL909918 | 0.91 | PIK3CB (0.83) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL12847243 | 0.91 | PIK3CA (0.79) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL477297 | 0.91 | PIK3CA (0.66) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL909981 | 0.91 | PIK3CA (0.78) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL3563102 | 0.90 | PIK3CB (1.00) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL477337 | 0.90 | PIK3CA (0.79) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL910091 | 0.90 | PIK3CA (0.77) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL909399 | 0.90 | PIK3CA (0.77) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL909178 | 0.89 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL908347 | 0.89 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276750-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | Auckland Uniservices Limited (NZ) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009120094-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-10-01 | — | — | WO | disclosed |