Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 3/20 | 0.43 |
| ▸ | RXRB | P28702 | 3/20 | 0.43 |
| ▸ | RXRG | P48443 | 3/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11387048 | 0.75 | ALDH1A1 (0.40) | MAPK14POLBL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL17542643 | 0.74 | CMA1 (0.44) | HTTL3MBTL1SMN1; SMN2LMNAMAPT | |
| SCHEMBL12559634 | 0.73 | BRD4 (0.51) | BRD4RXRARXRBRXRGHTT | |
| SCHEMBL11385796 | 0.71 | ALDH1A1 (0.41) | BRD4POLBRXRARXRBRXRG | |
| SCHEMBL98551 | 0.70 | FFAR1 (0.42) | HPGD | |
| SCHEMBL11477101 | 0.70 | HTT (0.45) | MAPK14RXRARXRBRXRGHTT | |
| SCHEMBL290791 | 0.70 | POLB (0.70) | POLBL3MBTL1MAPTMEN1ALDH1A1 | |
| SCHEMBL97064 | 0.70 | HCRTR1 (0.47) | BRD4 | |
| SCHEMBL97250 | 0.70 | BRD4 (0.48) | BRD4POLBEGLN1HTTL3MBTL1 | |
| SCHEMBL11394040 | 0.69 | CYP19A1 (0.45) | MAPK14HTTL3MBTL1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576324-A | Quinoline derivatives or salt thereof and remedy for cardiac diseases containing the same | KOWA CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0638571-A1 | QUINOLINE DERIVATIVE OR SALT THEREOF AND REMEDY FOR CARDIAC DISEASES CONTAINING THE SAME | KOWA CO. LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |