Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.64 |
| ▸ | PPARA | Q07869 | 15/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 15/20 | 0.64 |
| ▸ | PTGES | O14684 | 12/20 | 0.60 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099026 | 1.00 | PPARG (0.64) | PPARGPPARAALOX5PTGESFOLH1 | |
| SCHEMBL22612343 | 1.00 | PPARG (0.64) | PPARGPPARAALOX5PTGESFOLH1 | |
| SCHEMBL8356987 | 1.00 | PPARG (0.64) | PPARGPPARAALOX5PTGESFOLH1 | |
| SCHEMBL5081085 | 0.98 | PPARG (0.66) | PPARGPPARAALOX5PTGESFOLH1 | |
| SCHEMBL5080497 | 0.93 | PPARG (0.72) | PPARGPPARAALOX5PTGESFOLH1 | |
| SCHEMBL2351097 | 0.86 | PPARG (0.58) | PPARGPPARAALOX5PTGESFOLH1 | |
| SCHEMBL6935204 | 0.86 | PPARG (0.56) | PPARGPPARAALOX5PTGES | |
| SCHEMBL8318755 | 0.85 | PPARG (0.55) | PPARGPPARAALOX5PTGES | |
| SCHEMBL8856146 | 0.85 | PPARG (0.52) | PPARGPPARAALOX5PTGES | |
| SCHEMBL6935114 | 0.84 | PPARG (0.65) | PPARGPPARAALOX5PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498786-A | Synthesis of intermediates in the preparation of ACAT inhibitors | PFIZER INC. (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0569482-B1 | SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ACAT INHIBITORS | PFIZER (US) | 1995-08-02 | — | — | EP | disclosed |
| WO-1992013843-A1 | SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ACAT INHIBITORS | PFIZER INC. (US) | 1992-08-20 | — | — | WO | disclosed |