Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.52 |
| ▸ | PPARA | Q07869 | 9/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.52 |
| ▸ | PTGES | O14684 | 6/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612343 | 0.85 | PPARG (0.64) | PPARGPPARAALOX5PTGES | |
| SCHEMBL9099026 | 0.85 | PPARG (0.64) | PPARGPPARAALOX5PTGES | |
| SCHEMBL9099036 | 0.85 | PPARG (0.64) | PPARGPPARAALOX5PTGES | |
| SCHEMBL8356987 | 0.85 | PPARG (0.64) | PPARGPPARAALOX5PTGES | |
| SCHEMBL10498869 | 0.83 | NPC1 (0.46) | PPARGPPARAALOX5PTGESMMP9 | |
| SCHEMBL5081085 | 0.83 | PPARG (0.66) | PPARGPPARAALOX5PTGES | |
| SCHEMBL10403934 | 0.83 | PPARG (0.47) | PPARGPPARAALOX5PTGESMMP9 | |
| SCHEMBL10498132 | 0.79 | PPARG (0.48) | PPARGPPARAALOX5PTGESMMP9 | |
| SCHEMBL5080497 | 0.79 | PPARG (0.72) | PPARGPPARAALOX5PTGES | |
| SCHEMBL7656991 | 0.78 | PPARG (0.56) | PPARGPPARAALOX5PTGESMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5498786-A | Synthesis of intermediates in the preparation of ACAT inhibitors | PFIZER INC. (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0569482-B1 | SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ACAT INHIBITORS | PFIZER (US) | 1995-08-02 | — | — | EP | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1992013843-A1 | SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ACAT INHIBITORS | PFIZER INC. (US) | 1992-08-20 | — | — | WO | disclosed |