Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9100009 | 1.00 | TSHR (0.62) | TSHRTHRBHTTPOLBAPEX1 | |
| SCHEMBL2121560 | 0.98 | TSHR (0.59) | TSHRTHRBHTTPOLBAPEX1 | |
| SCHEMBL13432061 | 0.95 | THRB (0.56) | TSHRTHRBHTTPOLBAPEX1 | |
| SCHEMBL2120143 | 0.95 | THRB (0.56) | TSHRTHRBHTTPOLBAPEX1 | |
| SCHEMBL8850412 | 0.93 | TSHR (0.61) | TSHRTHRBHTTPOLBAPEX1 | |
| SCHEMBL12332609 | 0.93 | TSHR (0.61) | TSHRTHRBHTTPOLBAPEX1 | |
| SCHEMBL8851557 | 0.93 | TSHR (0.61) | TSHRTHRBHTTPOLBAPEX1 | |
| SCHEMBL8850574 | 0.93 | TSHR (0.61) | TSHRTHRBHTTPOLBAPEX1 | |
| SCHEMBL24591471 | 0.91 | THRB (0.56) | TSHRTHRBHTTPOLBAPEX1 | |
| SCHEMBL2696366 | 0.91 | THRB (0.61) | TSHRTHRBHTTPOLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576012-A | Pharmaceutical aqueous formulations containing a sparingly soluble pharmaceutical active compound with a solubilizing polymeric agent | BAUER KURT H (DE) | 1996-11-19 | — | — | US | claimed |
| US-5576012-A | Pharmaceutical aqueous formulations containing a sparingly soluble pharmaceutical active compound with a solubilizing polymeric agent | BAUER KURT H (DE) | 1996-11-19 | — | — | US | disclosed |