Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9100757 | 0.91 | PTAFR (0.48) | PTAFRNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL7666317 | 0.91 | PTAFR (0.48) | PTAFRNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9100513 | 0.89 | NPC1 (0.47) | PTAFRNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9691132 | 0.81 | PTAFR (0.53) | PTAFRNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10448547 | 0.81 | PTAFR (0.58) | PTAFRRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9691701 | 0.78 | PTAFR (0.52) | PTAFRNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10448821 | 0.78 | PTAFR (0.57) | PTAFRRAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9859957 | 0.76 | PTAFR (0.45) | PTAFRRAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9859903 | 0.76 | PTAFR (0.45) | PTAFRRAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9100958 | 0.75 | NPC1 (0.48) | NPC1HPGDRAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402151-B1 | New 2, 5-diaryl tetrahydrofurans and analogs thereof as paf antagonists | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5114961-A | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO., INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4996203-A | Platelet-activating factor antagonists | MERCK & CO., INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0402150-A1 | New 2,5-diaryl tetrahydrofurans and analogs therof as PAF antagonists | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |
| EP-0402151-A1 | New 2, 5-diaryl tetrahydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4977146-A | ANTICOAGULANT | MERCK & CO., INC. (US) | 1990-12-11 | — | — | US | disclosed |