Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109885 | 0.89 | PTAFR (0.61) | PTAFRRAB9ASMN1; SMN2 | |
| SCHEMBL9100513 | 0.89 | NPC1 (0.47) | PTAFRNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9692071 | 0.88 | SMN1; SMN2 (0.47) | PTAFRNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9691100 | 0.87 | SMN1; SMN2 (0.45) | NPC1HPGDRAB9ASMN1; SMN2ABCB1 | |
| SCHEMBL9691132 | 0.83 | PTAFR (0.53) | PTAFRNPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9691535 | 0.81 | PTAFR (0.81) | PTAFR | |
| SCHEMBL9691538 | 0.81 | PTAFR (0.81) | PTAFR | |
| SCHEMBL9691546 | 0.81 | PTAFR (0.81) | PTAFR | |
| SCHEMBL9100958 | 0.80 | NPC1 (0.48) | NPC1HPGDRAB9ASMN1; SMN2ABCB1 | |
| SCHEMBL9099229 | 0.78 | PTAFR (0.43) | PTAFRNPC1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114961-A | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO., INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4996203-A | Platelet-activating factor antagonists | MERCK & CO., INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0402150-A1 | New 2,5-diaryl tetrahydrofurans and analogs therof as PAF antagonists | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |
| EP-0402151-A1 | New 2, 5-diaryl tetrahydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4977146-A | ANTICOAGULANT | MERCK & CO., INC. (US) | 1990-12-11 | — | — | US | disclosed |