Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.76 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.76 |
| ▸ | ESRRG | P62508 | 5/20 | 0.76 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HTR6 | P50406 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.55 |
| ▸ | ESRRB | O95718 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL906340 | 1.00 | ESR1 (0.76) | ESR1CYP19A1ESRRGESR2LMNA | |
| SCHEMBL906339 | 1.00 | ESR1 (0.76) | ESR1CYP19A1ESRRGESR2LMNA | |
| SCHEMBL906306 | 0.95 | HTR6 (0.69) | ESR1CYP19A1ESRRGESR2LMNA | |
| SCHEMBL906307 | 0.95 | HTR6 (0.69) | ESR1CYP19A1ESRRGESR2LMNA | |
| SCHEMBL5725379 | 0.95 | HTR6 (0.69) | ESR1CYP19A1ESRRGESR2LMNA | |
| SCHEMBL9097768 | 0.91 | ESR1 (0.63) | ESR1CYP19A1ESRRGESR2LMNA | |
| SCHEMBL9097781 | 0.91 | ESR1 (0.63) | ESR1CYP19A1ESRRGESR2LMNA | |
| SCHEMBL9097774 | 0.91 | ESR1 (0.63) | ESR1CYP19A1ESRRGESR2LMNA | |
| SCHEMBL23183595 | 0.89 | ESR1 (0.82) | ESR1CYP19A1ESRRGESR2CYP1A2 | |
| Endoxifen SCHEMBL14391818 | 0.86 | ESR1 (1.00) | ESR1CYP19A1ESRRGESR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011129837-A1 | USE OF A 4-HYDROXYTOREMIFENE PRODRUG FOR TREATMENT OF BREAST CANCER | OLEMA PHARMACEUTICALS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |
| US-5491173-A | ESTROGENIC, ANTIESTROGENIC AGENTS, ANTITUMOR AGENTS | ORION-YHTYMA OY (FI) | 1996-02-13 | — | — | US | disclosed |