Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | HTT | P42858 | 7/20 | 0.44 |
| ▸ | MITF | O75030 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099716 | 1.00 | MAPT (0.44) | MAPTALDH1A1HTTMITFKDM4E | |
| SCHEMBL8427595 | 0.85 | MAPT (0.39) | MAPTALDH1A1HTTMITFKDM4E | |
| SCHEMBL8427588 | 0.85 | MAPT (0.39) | MAPTALDH1A1HTTMITFKDM4E | |
| SCHEMBL8427593 | 0.85 | MAPT (0.39) | MAPTALDH1A1HTTMITFKDM4E | |
| SCHEMBL8425885 | 0.84 | PKM (0.49) | MAPTALDH1A1HTTMITFKDM4E | |
| SCHEMBL8425883 | 0.84 | PKM (0.49) | MAPTALDH1A1HTTMITFKDM4E | |
| SCHEMBL8425886 | 0.84 | PKM (0.49) | MAPTALDH1A1HTTMITFKDM4E | |
| SCHEMBL8425618 | 0.83 | PKM (0.51) | MAPTALDH1A1HTTMITFKDM4E | |
| SCHEMBL8425615 | 0.83 | PKM (0.51) | MAPTALDH1A1HTTMITFKDM4E | |
| SCHEMBL8425622 | 0.83 | PKM (0.51) | MAPTALDH1A1HTTMITFKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996040675-A1 | THIENYL COMPOUNDS FOR INHIBITION OF CELL PROLIFERATIVE DISORDERS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | claimed |
| WO-1996040675-A1 | THIENYL COMPOUNDS FOR INHIBITION OF CELL PROLIFERATIVE DISORDERS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |