Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.58 |
| ▸ | TK1 | P04183 | 5/20 | 0.48 |
| ▸ | TK2 | O00142 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9098818 | 0.92 | LMNA (0.62) | LMNASMN1; SMN2RNASE1TK1TK2 | |
| SCHEMBL9098812 | 0.92 | LMNA (0.62) | LMNASMN1; SMN2RNASE1TK1TK2 | |
| SCHEMBL9100588 | 0.90 | LMNA (0.59) | LMNASMN1; SMN2RNASE1TK1TK2 | |
| SCHEMBL9100584 | 0.90 | LMNA (0.59) | LMNASMN1; SMN2RNASE1TK1TK2 | |
| SCHEMBL9099906 | 0.90 | LMNA (0.59) | LMNASMN1; SMN2RNASE1TK1TK2 | |
| SCHEMBL9099281 | 0.90 | LMNA (0.59) | LMNASMN1; SMN2RNASE1TK1TK2 | |
| SCHEMBL10563133 | 0.88 | LMNA (0.62) | LMNASMN1; SMN2RNASE1TK1TK2 | |
| SCHEMBL10563130 | 0.88 | LMNA (0.62) | LMNASMN1; SMN2RNASE1TK1TK2 | |
| SCHEMBL9099909 | 0.88 | LMNA (0.57) | LMNASMN1; SMN2RNASE1TK1TK2 | |
| SCHEMBL9099904 | 0.88 | LMNA (0.57) | LMNASMN1; SMN2RNASE1TK1TK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0323441-B1 | 5-Fluorouracil derivatives | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5155113-A | Administering 5-fluorouracil and derivatives with pyridine and pyridone derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| US-4983609-A | Anticancer agents | OTSUKA PHARMACEUTICAL (JP) | 1991-01-08 | — | — | US | disclosed |
| US-4864021-A | ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0323441-A2 | 5-Fluorouracil derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-05 | — | — | EP | disclosed |
| EP-0180897-A2 | 5-Fluorouracil derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-14 | — | — | EP | disclosed |