Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103558 | 0.89 | KCNH2 (0.47) | MAP2K1KCNH2MAP2K2MAP2K5 | |
| SCHEMBL9101056 | 0.88 | MAP2K1 (0.53) | MAP2K1KCNH2MAP2K2BRAFMAPK1 | |
| SCHEMBL1976550 | 0.87 | MAP2K1 (0.52) | MAP2K1KCNH2MAP2K2BRAFMAPK1 | |
| SCHEMBL12590281 | 0.79 | KCNH2 (0.55) | MAP2K1KCNH2MAP2K2MAPK1MAP2K5 | |
| SCHEMBL15234371 | 0.76 | KCNH2 (0.59) | MAP2K1KCNH2MAP2K2BRAFMAPK1 | |
| SCHEMBL9104105 | 0.76 | KCNH2 (0.62) | MAP2K1KCNH2MAP2K2MAP2K5 | |
| SCHEMBL15234331 | 0.76 | CYP2C9 (0.59) | MAP2K1KCNH2MAP2K2BRAFMAPK1 | |
| SCHEMBL1977165 | 0.75 | KCNH2 (0.59) | MAP2K1KCNH2MAP2K2MAP2K5 | |
| SCHEMBL1977779 | 0.74 | MAP2K1 (0.66) | MAP2K1KCNH2MAP2K2BRAFMAPK1 | |
| SCHEMBL9885440 | 0.74 | KCNH2 (0.53) | MAP2K1KCNH2MAP2K2MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220092-B1 | AZAINDOLIZINES AND METHODS OF USE | GENENTECH INC (US) | 2012-06-06 | — | — | EP | claimed |