Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.37 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9101063 | 0.89 | MAP2K1 (0.43) | KCNH2MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL9104105 | 0.87 | KCNH2 (0.62) | KCNH2CYP2C9MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL1977165 | 0.86 | KCNH2 (0.59) | KCNH2CYP2C9MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL9885440 | 0.81 | KCNH2 (0.53) | KCNH2CYP2C9MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL1615224 | 0.78 | KCNH2 (0.76) | KCNH2CYP2C9MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL1976121 | 0.77 | KCNH2 (0.47) | KCNH2CYP2C9MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL1977219 | 0.76 | MAP2K2 (0.41) | KCNH2CYP2C9MAP2K1MAP2K2CYP2C19 | |
| SCHEMBL1980901 | 0.76 | MAP2K1 (0.43) | KCNH2CYP2C9MAP2K1MAP2K2 | |
| SCHEMBL12646887 | 0.76 | CYP2C9 (0.76) | KCNH2CYP2C9MAP2K1MAP2K2MAP2K5 | |
| SCHEMBL9101056 | 0.76 | MAP2K1 (0.53) | KCNH2MAP2K1MAP2K2MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220092-B1 | AZAINDOLIZINES AND METHODS OF USE | GENENTECH INC (US) | 2012-06-06 | — | — | EP | claimed |