Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.39 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9435886 | 0.82 | F12 (0.47) | EGFRKDRMAPTHTTKMT2A | |
| SCHEMBL11572129 | 0.78 | NPC1 (0.48) | EGFRPDGFRBFGFR1KDRALDH1A1 | |
| SCHEMBL9436106 | 0.75 | EGFR (0.41) | EGFRPDGFRBFGFR1KDRALDH1A1 | |
| SCHEMBL7568567 | 0.73 | EGFR (0.56) | EGFRPDGFRBFGFR1KDRALDH1A1 | |
| SCHEMBL7575236 | 0.71 | NTRK1 (0.55) | EGFRMAPTKMT2AL3MBTL1NTRK1 | |
| SCHEMBL2681675 | 0.68 | ABCG2 (0.49) | ALDH1A1MAPTHTTKMT2ANTRK1 | |
| SCHEMBL7574891 | 0.68 | NTRK1 (0.44) | EGFRALDH1A1MAPTKMT2ARAB9A | |
| SCHEMBL29892465 | 0.66 | MAPT (0.68) | GRK6KEAP1NFE2L2FGFR1ALDH1A1 | |
| SCHEMBL27157150 | 0.66 | MAPT (0.68) | GRK6KEAP1NFE2L2FGFR1ALDH1A1 | |
| SCHEMBL7570053 | 0.66 | SOS1 (0.56) | EGFRALDH1A1MAPTHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5543631-A | N-2''-PYRIDYL-8,13-DIOXODINAPHTHO(2,1-B:2',3'-D)FURAN-6-CARBO XAMIDE, SWITCHES | WEINBERGER LESTER (US) | 1996-08-06 | — | — | US | disclosed |