Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.68 |
| ▸ | MEN1 | O00255 | 7/20 | 0.68 |
| ▸ | HTT | P42858 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.68 |
| ▸ | APAF1 | O14727 | 2/20 | 0.68 |
| ▸ | CASP3 | P42574 | 1/20 | 0.68 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.68 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.68 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.55 |
| ▸ | CDC25A | P30304 | 1/20 | 0.55 |
| ▸ | CDC25B | P30305 | 1/20 | 0.55 |
| ▸ | CDC25C | P30307 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27157150 | 1.00 | MAPT (0.68) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL29362140 | 0.83 | MAPT (0.68) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL14657071 | 0.83 | MAPT (0.68) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL25649956 | 0.75 | ADORA2A (0.55) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL16167389 | 0.72 | NQO1 (0.53) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL30601020 | 0.72 | MAPT (0.53) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL7121384 | 0.72 | KEAP1 (0.86) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL7829487 | 0.72 | KEAP1 (0.73) | MAPTALDH1A1HTTLMNAKEAP1 | |
| SCHEMBL16167167 | 0.72 | MAPT (0.53) | MAPTALDH1A1KMT2AMEN1HTT | |
| SCHEMBL801214 | 0.71 | MAPT (1.00) | MAPTALDH1A1KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230010562-A1 | 4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-3-CARBOXAMIDE DERIVATIVES AND USES THEREOF FOR TREATING PROLIFERATIVE DISEASES AND INFECTIOUS DISEASES | ACADEMIA SINICA (TW) | 2023-01-12 | — | — | US | disclosed |
| US-11434229-B2 | 4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases | ACADEMIA SINICA (TW) | 2022-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230010562-A1 | 4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-B]FURAN-3-CARBOXAMIDE DERIVATIVES AND USES THEREOF FOR TREATING PROLIFERATIVE DISEASES AND INFECTIOUS DISEASES | DHODH, NQO2, PKD1 | MAPT 4228/4885ALDH1A1 199/4885KMT2A 2900/4885 |
| US-11434229-B2 | 4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases | DHODH, NQO2, PKD1 | MAPT 4228/4885ALDH1A1 199/4885KMT2A 2900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.