Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574332 | 0.81 | KCNH2 (1.00) | HRH3KCNH2 | |
| SCHEMBL9104832 | 0.80 | HRH3 (0.69) | HRH3KCNH2 | |
| SCHEMBL9107876 | 0.80 | HRH3 (0.69) | HRH3KCNH2 | |
| SCHEMBL9102435 | 0.79 | HRH3 (0.70) | HRH3KCNH2KDM4E | |
| SCHEMBL9105288 | 0.79 | HRH3 (0.57) | HRH3KCNH2 | |
| SCHEMBL9105208 | 0.79 | HRH3 (0.66) | HRH3KCNH2 | |
| SCHEMBL9102223 | 0.79 | HRH3 (0.71) | HRH3KCNH2 | |
| SCHEMBL9101614 | 0.79 | HRH3 (0.69) | HRH3KCNH2 | |
| SCHEMBL9108354 | 0.73 | HRH3 (0.67) | HRH3KCNH2 | |
| SCHEMBL9106427 | 0.72 | HRH3 (0.49) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751149-B1 | BICYCLIC-SUBSTITUTED AMINES HAVING CYCLIC-SUBSTITUTED MONOCYCLIC SUBSTITUENTS | ABBOTT LAB (US) | 2012-06-06 | — | — | EP | claimed |