Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212981 | 0.90 | TP53 (0.58) | TP53MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL9099785 | 0.87 | TP53 (0.56) | TP53MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL9099840 | 0.85 | MAPT (0.58) | MAPTLMNASMN1; SMN2KMT2ATHRB | |
| SCHEMBL9101209 | 0.83 | TP53 (0.54) | TP53MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL9102280 | 0.82 | TP53 (0.52) | TP53MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL8401275 | 0.81 | HDAC3 (0.53) | TP53MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL9098669 | 0.81 | MAPT (0.46) | TP53MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL9098233 | 0.80 | TP53 (0.53) | TP53MAPTKMT2ATHRBPOLB | |
| SCHEMBL12142337 | 0.78 | TP53 (0.49) | TP53MAPTLMNASMN1; SMN2KMT2A | |
| SCHEMBL8936588 | 0.77 | MAPT (0.50) | MAPTLMNASMN1; SMN2KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550122-A | INHIBIT REVERSE TRANSCRIPTASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0415303-B1 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMA (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0415303-A2 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1991-03-06 | — | — | EP | disclosed |