Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9101435 | 0.83 | TP53 (0.60) | TP53LMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL9212981 | 0.81 | TP53 (0.58) | TP53LMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL9099785 | 0.79 | TP53 (0.56) | TP53LMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL8936638 | 0.76 | BRD4 (0.44) | TP53LMNAMAPTSMN1; SMN2CASP3 | |
| SCHEMBL9102280 | 0.76 | TP53 (0.52) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8936648 | 0.76 | TP53 (0.45) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8936654 | 0.76 | TP53 (0.45) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8936579 | 0.73 | CASP3 (0.44) | LMNAMAPTSMN1; SMN2CASP3ALDH1A1 | |
| SCHEMBL12142337 | 0.73 | TP53 (0.49) | TP53LMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL9010372 | 0.73 | ALDH1A1 (0.51) | LMNAMAPTSMN1; SMN2CASP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550122-A | INHIBIT REVERSE TRANSCRIPTASE | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| EP-0415303-B1 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMA (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0415303-A2 | Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1991-03-06 | — | — | EP | disclosed |