Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 3/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720617 | 0.94 | CRBN (0.45) | PDE7ACRBNKCNQ3KCNQ2PIK3CA | |
| SCHEMBL4826982 | 0.94 | CRBN (0.45) | PDE7ACRBNKCNQ3KCNQ2PIK3CA | |
| SCHEMBL2698179 | 0.91 | CRBN (0.48) | PDE7ACRBNKCNQ3KCNQ2PIK3CA | |
| SCHEMBL3704498 | 0.91 | CRBN (0.48) | PDE7ACRBNKCNQ3KCNQ2PIK3CA | |
| SCHEMBL3704501 | 0.91 | CRBN (0.48) | PDE7ACRBNKCNQ3KCNQ2PIK3CA | |
| SCHEMBL2698177 | 0.91 | CRBN (0.48) | PDE7ACRBNKCNQ3KCNQ2PIK3CA | |
| SCHEMBL10112705 | 0.83 | CRBN (0.45) | PDE7ACRBNTRPV1RAB9AL3MBTL1 | |
| SCHEMBL551023 | 0.83 | CRBN (0.59) | PDE7ACRBNKCNQ3KCNQ2PIK3CA | |
| SCHEMBL551024 | 0.83 | CRBN (0.59) | PDE7ACRBNKCNQ3KCNQ2PIK3CA | |
| SCHEMBL2699729 | 0.83 | CRBN (0.59) | PDE7ACRBNKCNQ3KCNQ2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193207-B2 | Lactam compounds and methods of using the same | INCYTE CORPORATION (US) | 2012-06-05 | — | — | US | disclosed |