Sugi Predict

Sugi Predict / Compounds / SCHEMBL3704501

SCHEMBL3704501

SCHEMBL3704501

O=C(O)Nc1ccc(N2CCC[C@]3(CCN(C4CCC(O)CC4)C3=O)C2)nc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 3/20 0.48
▸ PDE7A Q13946 2/20 0.39
▸ DDB1 Q16531 1/20 0.38
▸ KCNQ3 O43525 1/20 0.37
▸ KCNQ2 O43526 1/20 0.37
▸ PIK3CA P42336 1/20 0.37
▸ FASN P49327 2/20 0.35
▸ L3MBTL1 Q9Y468 2/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ MAPT P10636 2/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ TRPV1 Q8NER1 2/20 0.35
▸ DGAT1 O75907 1/20 0.35
▸ GSK3B P49841 1/20 0.35
▸ DYRK1A Q13627 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ KCNH2 Q12809 1/20 0.35
▸ MCHR1 Q99705 1/20 0.35
▸ JAK2 O60674 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2698177 1.00 CRBN (0.48) CRBNPDE7ADDB1KCNQ3KCNQ2
SCHEMBL3704498 1.00 CRBN (0.48) CRBNPDE7ADDB1KCNQ3KCNQ2
SCHEMBL2698179 1.00 CRBN (0.48) CRBNPDE7ADDB1KCNQ3KCNQ2
SCHEMBL551023 0.91 CRBN (0.59) CRBNPDE7ADDB1KCNQ3KCNQ2
SCHEMBL550039 0.91 CRBN (0.59) CRBNPDE7ADDB1KCNQ3KCNQ2
SCHEMBL551024 0.91 CRBN (0.59) CRBNPDE7ADDB1KCNQ3KCNQ2
SCHEMBL9101854 0.91 PDE7A (0.42) CRBNPDE7AKCNQ3KCNQ2PIK3CA
SCHEMBL2699725 0.91 CRBN (0.59) CRBNPDE7ADDB1KCNQ3KCNQ2
SCHEMBL2699729 0.91 CRBN (0.59) CRBNPDE7ADDB1KCNQ3KCNQ2
SCHEMBL550038 0.91 CRBN (0.59) CRBNPDE7ADDB1KCNQ3KCNQ2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8563570-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2013-10-22 — — US claimed
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US claimed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US claimed
US-8563570-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2013-10-22 — — US disclosed
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US disclosed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 CRBN 2898/4885PDE7A 251/4885DDB1 3426/4885
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 CRBN 2898/4885PDE7A 251/4885DDB1 3426/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.