Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.41 |
| ▸ | CCNK | O75909 | 5/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16029804 | 0.80 | PRKCI (0.36) | PRKCIAXLNUDT1CCNKCDK12 | |
| SCHEMBL239630 | 0.73 | NUDT1 (0.54) | PRKCIAXLNUDT1CCNKCDK12 | |
| SCHEMBL13069320 | 0.70 | PRKCI (0.50) | PRKCIAXLNUDT1CCNKCDK12 | |
| SCHEMBL14416607 | 0.70 | PRKCI (0.50) | PRKCIAXLNUDT1CCNKCDK12 | |
| SCHEMBL3692295 | 0.70 | CIT (0.34) | PRKCINUDT1CCNKCDK12AURKB | |
| SCHEMBL3088057 | 0.70 | PRKCI (0.58) | PRKCIAXLNUDT1CCNKCDK12 | |
| SCHEMBL1752655 | 0.70 | PRKCI (0.53) | PRKCIAXLNUDT1CCNKCDK12 | |
| SCHEMBL1748621 | 0.70 | PRKCI (0.53) | PRKCIAXLNUDT1CCNKCDK12 | |
| SCHEMBL14534111 | 0.70 | PRKCI (0.53) | PRKCIAXLNUDT1CCNKCDK12 | |
| SCHEMBL2602399 | 0.70 | PRKCI (0.53) | PRKCIAXLNUDT1CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103748095-A | Bicyclic heteroaromatic compounds | MERCK PATENT GMBH | 2014-04-23 | — | — | CN | disclosed |
| EP-2458991-A1 | RADIOLABELED CGRP ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2012-06-06 | — | — | EP | disclosed |