Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pidolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAD | P27708 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pidolic Acid SCHEMBL9102233 | 1.00 | CAD (0.40) | CADGAAITGB3ITGB2ITGB1 | |
| Pidolic Acid SCHEMBL1239532 | 0.90 | CAD (0.46) | CADGAALMNASMN1; SMN2MEN1 | |
| Pidolic Acid SCHEMBL223918 | 0.90 | — | — | |
| Pidolic Acid SCHEMBL15790 | 0.90 | — | — | |
| Pidolic Acid SCHEMBL152441 | 0.90 | CAD (0.46) | CADGAALMNASMN1; SMN2MEN1 | |
| Pidolic Acid SCHEMBL29479230 | 0.90 | — | — | |
| Pidolic Acid SCHEMBL7554345 | 0.90 | CAD (0.46) | CADGAALMNASMN1; SMN2MEN1 | |
| Pidolic Acid SCHEMBL15791 | 0.90 | — | — | |
| Pidolic Acid SCHEMBL10937920 | 0.90 | CAD (0.46) | CADGAALMNASMN1; SMN2MEN1 | |
| Pidolic Acid SCHEMBL2059368 | 0.89 | CAD (0.40) | CADGAAITGB3ITGB2ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3113937-B1 | IMPROVED CLEANING METHOD FOR MOLDS USED IN THE MANUFACTURING OF SILICONE HYDROGEL CONTACT LENSES | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | claimed |
| EP-3113937-A1 | IMPROVED CLEANING METHOD FOR MOLDS USED IN THE MANUFACTURING OF SILICONE HYDROGEL CONTACT LENSES | Novartis AG (CH) | 2017-01-11 | — | — | EP | claimed |
| US-9156215-B2 | Method for making silicone hydrogel contact lenses | NOVARTIS AG (CH) | 2015-10-13 | — | — | US | claimed |
| WO-2015132277-A1 | IMPROVED CLEANING METHOD FOR MOLDS USED IN THE MANUFACTURING OF SILICONE HYDROGEL CONTACT LENSES | NOVARTIS AG (CH) | 2015-09-11 | — | — | WO | claimed |
| US-20150251364-A1 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES | CIBA VISION GMBH (DE) | 2015-09-10 | — | — | US | claimed |
| EP-2648896-B1 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES | NOVARTIS AG (CH) | 2014-09-17 | — | — | EP | claimed |
| EP-2648896-A1 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES | Novartis AG (CH) | 2013-10-16 | — | — | EP | claimed |
| WO-2012078457-A1 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES | NOVARTIS AG (CH) | 2012-06-14 | — | — | WO | claimed |
| US-20120139138-A1 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES | ALCON INC. (CH) | 2012-06-07 | — | — | US | claimed |