Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.39 |
| ▸ | CHUK | O15111 | 6/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 7/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554397 | 0.82 | DAO (0.36) | IKBKBCHUKNPY5RCDK9CCNT1 | |
| SCHEMBL90907 | 0.81 | NPY5R (0.38) | IKBKBCHUKNPY5RCYP2C9CDK9 | |
| SCHEMBL91019 | 0.80 | IKBKB (0.35) | IKBKBCHUKNPY5RTDP1 | |
| SCHEMBL8577264 | 0.79 | NPY5R (0.34) | IKBKBCHUKNPY5RBRD4PTGDR | |
| SCHEMBL8526567 | 0.78 | PDK2 (0.41) | IKBKBCHUKNPY5RCDK9CCNT1 | |
| SCHEMBL90914 | 0.77 | NPY5R (0.34) | IKBKBCHUKNPY5RCDK9BRD4 | |
| SCHEMBL90918 | 0.77 | NPY5R (0.36) | IKBKBCHUKNPY5RCDK9BRD4 | |
| SCHEMBL90993 | 0.76 | CDK9 (0.33) | IKBKBCHUKNPY5RCDK9CCNT1 | |
| SCHEMBL90942 | 0.74 | PDK2 (0.38) | IKBKBCHUKNPY5RCDK9BRD4 | |
| SCHEMBL90916 | 0.74 | IKBKB (0.36) | IKBKBCHUKNPY5RCYP2C9CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299066-B2 | Compounds having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |
| US-20120130070-A1 | COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-05-24 | — | — | US | disclosed |
| US-8129372-B2 | Compounds having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2012-03-06 | — | — | US | disclosed |
| US-20110028468-A1 | COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | Shinonogi & Co., Ltd (JP) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130070-A1 | COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | NPY5R, NPY1R, NPY2R | IKBKB 2117/4885CHUK 754/4885NPY5R 1/4885 |
| US-20110028468-A1 | COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | NPY5R, NPY1R, NPY2R | IKBKB 2117/4885CHUK 754/4885NPY5R 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.