Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.50 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380435 | 0.92 | RAF1 (0.46) | RAF1RETMAPTMEN1KMT2A | |
| SCHEMBL9101755 | 0.91 | RET (0.55) | RAF1RETMEN1KMT2ABRAF | |
| SCHEMBL4466716 | 0.88 | RAF1 (0.65) | RAF1RETMEN1KMT2ABRAF | |
| SCHEMBL9098846 | 0.88 | KDR (0.49) | RAF1RETMAPTBRAFKDR | |
| SCHEMBL9099762 | 0.85 | KDR (0.42) | RAF1RETMAPTBRAFRAB9A | |
| SCHEMBL5724635 | 0.84 | KDR (0.53) | RAF1RETBRAFRAB9AKDR | |
| SCHEMBL9100193 | 0.84 | CDK8 (0.42) | RAF1RETMEN1KMT2ALMNA | |
| SCHEMBL9102135 | 0.83 | RAF1 (0.55) | RAF1RETMEN1KMT2ABRAF | |
| SCHEMBL9102040 | 0.83 | CDK8 (0.45) | RETMAPTMEN1KMT2ALMNA | |
| SCHEMBL9104786 | 0.80 | RAF1 (0.49) | RAF1RETMAPTLMNABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | claimed |
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | disclosed |