Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694999 | 0.94 | MAPT (0.49) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL3694901 | 0.93 | MAPT (0.47) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9103782 | 0.91 | MAPT (0.48) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9107477 | 0.91 | MAPT (0.49) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3693912 | 0.91 | MAPT (0.47) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9108290 | 0.91 | MAPT (0.45) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9107165 | 0.90 | MAPT (0.47) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL3701993 | 0.89 | MAPT (0.47) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9107195 | 0.89 | MEN1 (0.41) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9104342 | 0.89 | MAPT (0.41) | MAPTMEN1KMT2APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460798-A2 | APAF-1 INHIBITOR COMPOUNDS | Laboratorios SALVAT, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |