Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9105309 | 0.89 | MAPT (0.47) | MAPTTP53MEN1KMT2APOLB | |
| SCHEMBL3698675 | 0.89 | ALDH1A1 (0.47) | MAPTMEN1KMT2AALDH1A1HDAC8 | |
| SCHEMBL9107195 | 0.87 | MEN1 (0.41) | MAPTTP53MEN1KMT2APOLB | |
| SCHEMBL9102425 | 0.85 | MAPT (0.44) | MAPTTP53MEN1KMT2APOLB | |
| SCHEMBL9103931 | 0.84 | ITGB2 (0.44) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9102458 | 0.84 | MAPT (0.42) | MAPTTP53MEN1KMT2APOLB | |
| SCHEMBL3700824 | 0.84 | ITGB2 (0.37) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL9105229 | 0.84 | ITGB2 (0.39) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL3694999 | 0.83 | MAPT (0.49) | MAPTTP53MEN1KMT2APOLB | |
| SCHEMBL9101222 | 0.83 | ITGB2 (0.39) | MAPTMEN1KMT2APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460798-A2 | APAF-1 INHIBITOR COMPOUNDS | Laboratorios SALVAT, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |