Hydrochlorthiazide

Hydrochlorthiazide

SCHEMBL9106040

Brc1nccs1.c1cscn1

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
TSHR P16473 1/20 0.36
NOS1 P29475 1/20 0.36
HSD17B10 Q99714 1/20 0.36
FBP1 P09467 2/20 0.33
PDK1 Q15118 1/20 0.33
ADORA2A P29274 1/20 0.30
HDAC8 Q9BY41 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6063 0.81
Aminothiazole SCHEMBL28028506 0.78 ALDH1A1 (0.65) ALDH1A1TSHRNOS1HSD17B10FBP1
SCHEMBL7608425 0.78
SCHEMBL28154798 0.78
SCHEMBL7848 0.78
Ammonia Solution, Strong SCHEMBL28250933 0.78
SCHEMBL27748983 0.78
SCHEMBL6273421 0.78
Bromide SCHEMBL5403925 0.78
Hydrochlorthiazide SCHEMBL20873795 0.77 ALDH1A1 (0.34) ALDH1A1TSHRNOS1HSD17B10FBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0527186-A4 UNIV ILLINOIS (US) 1995-01-18 EP disclosed
EP-0527186-A1 PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS The Board of Trustees for the University of Illinois (US) 1993-02-17 EP disclosed
WO-1991016820-A1 PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 1991-11-14 WO disclosed