Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198304 | 0.78 | CA12 (0.34) | CA12CA1CA9LMNA | |
| SCHEMBL23733173 | 0.78 | CA12 (0.34) | CA12CA1CA9LMNA | |
| SCHEMBL317539 | 0.75 | CA12 (0.38) | CA12CA1CA9RAB9ASMN1; SMN2 | |
| SCHEMBL8500805 | 0.73 | TSHR (0.37) | CA12CA1CA9LMNAALDH1A1 | |
| SCHEMBL727395 | 0.73 | TSHR (0.37) | CA12CA1CA9LMNAALDH1A1 | |
| SCHEMBL887169 | 0.73 | NOTUM (0.42) | CA12CA1CA9SMN1; SMN2 | |
| SCHEMBL22425373 | 0.73 | MEN1 (0.47) | — | |
| SCHEMBL14363762 | 0.71 | GLA (0.31) | CA12CA1CA9 | |
| SCHEMBL23733015 | 0.71 | CA12 (0.35) | CA12CA1CA9ALDH1A1 | |
| SCHEMBL432175 | 0.71 | CA12 (0.35) | CA12CA1CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2446035-B1 | NOVEL DRUGS FOR INHIBITION OF GENE EXPRESSION | SYLENTIS SAU (ES) | 2015-03-11 | — | — | EP | disclosed |
| US-8703731-B2 | Sphingosine-bound siRNA | SYLENTIS S.A.U. (ES) | 2014-04-22 | — | — | US | disclosed |
| US-20120142765-A1 | Sphingosine-bound siRNA | SYLENTIS S.A.U. (ES) | 2012-06-07 | — | — | US | disclosed |
| CN-102317315-A | Albumin variants and conjugates | NOVOZYMES BIOPHARMA UK LTD | 2012-01-11 | — | — | CN | disclosed |