Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 3/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5585966 | 0.91 | MEN1 (0.48) | MEN1KMT2APOLBIGF1REPHB4 | |
| Cyclopropane SCHEMBL9104235 | 0.91 | EPHB4 (0.43) | MEN1KMT2AEPHB4MAPTKDM4E | |
| SCHEMBL9885353 | 0.90 | MEN1 (0.45) | MEN1KMT2APOLBIGF1REPHB4 | |
| Cyclopropane SCHEMBL9104865 | 0.89 | KDR (0.45) | MEN1KMT2AEPHB4MAPTKDM4E | |
| SCHEMBL5600303 | 0.88 | MEN1 (0.45) | MEN1KMT2APOLBIGF1REPHB4 | |
| SCHEMBL5959777 | 0.88 | MEN1 (0.45) | MEN1KMT2APOLBIGF1REPHB4 | |
| SCHEMBL5592576 | 0.88 | MEN1 (0.46) | MEN1KMT2APOLBIGF1REPHB4 | |
| SCHEMBL5592585 | 0.86 | MEN1 (0.47) | MEN1KMT2APOLBIGF1REPHB4 | |
| SCHEMBL5959896 | 0.86 | MEN1 (0.46) | MEN1KMT2APOLBIGF1REPHB4 | |
| SCHEMBL5600048 | 0.86 | MEN1 (0.57) | MEN1KMT2APOLBIGF1REPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858879-B1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT INC (US) | 2012-06-06 | — | — | EP | claimed |