Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | NEK4 | P51957 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.41 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL9107860 | 0.89 | BRAF (0.43) | KDREPHB4TEKBRAFHIPK4 | |
| Cyclopropane SCHEMBL9108474 | 0.89 | MEN1 (0.46) | EPHB4MAPTKDM4EMEN1LMNA | |
| Cyclopropane SCHEMBL9104235 | 0.89 | EPHB4 (0.43) | KDREPHB4TEKMAPTKDM4E | |
| SCHEMBL5586075 | 0.87 | KDR (0.47) | KDREPHB4TEKBRAFRAF1 | |
| SCHEMBL5586072 | 0.86 | KDR (0.47) | KDREPHB4TEKBRAFRAF1 | |
| SCHEMBL5593089 | 0.86 | EPHB4 (0.54) | KDREPHB4TEKBRAFRAF1 | |
| SCHEMBL5611567 | 0.81 | MAPK14 (0.47) | KDREPHB4TEKBRAFMAPK14 | |
| SCHEMBL5585966 | 0.80 | MEN1 (0.48) | EPHB4MAPTKDM4EMEN1LMNA | |
| SCHEMBL5585926 | 0.80 | KDR (0.44) | KDREPHB4TEKMAPTKDM4E | |
| SCHEMBL5586052 | 0.80 | KDR (0.44) | KDREPHB4TEKMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858879-B1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT INC (US) | 2012-06-06 | — | — | EP | claimed |