SCHEMBL9109079

SCHEMBL9109079

CCOC(=O)c1c(C)cc(C)n1-n1cccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
HTT P42858 2/20 0.43
ATM Q13315 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
ALDH1A1 P00352 4/20 0.42
GAA P10253 2/20 0.42
MAPT P10636 1/20 0.42
CA12 O43570 2/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA7 P43166 2/20 0.41
CA9 Q16790 2/20 0.41
CA14 Q9ULX7 2/20 0.41
KMT2A Q03164 3/20 0.41
CYP1A2 P05177 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
HPGD P15428 3/20 0.40
KDM4E B2RXH2 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11355497 0.75 KMT2A (0.50) SMN1; SMN2HTTALDH1A1GAAMAPT
SCHEMBL9108833 0.74 KMT2A (0.62) MAPK1SMN1; SMN2L3MBTL1ALDH1A1GAA
SCHEMBL15908731 0.73 CA12 (0.46) MAPK1SMN1; SMN2HTTALDH1A1GAA
SCHEMBL29712822 0.71 CA12 (0.43) MAPK1SMN1; SMN2HTTALDH1A1GAA
SCHEMBL31193390 0.71 ALDH1A1 (0.68) MAPK1SMN1; SMN2HTTALDH1A1GAA
SCHEMBL29123133 0.69 TSHR (0.71) MAPK1SMN1; SMN2ATML3MBTL1ALDH1A1
SCHEMBL21889641 0.68 CA12 (0.40) SMN1; SMN2HTTL3MBTL1ALDH1A1GAA
SCHEMBL11195139 0.67 KMT2A (0.49) SMN1; SMN2HTTALDH1A1GAAMAPT
SCHEMBL21889762 0.67 CA12 (0.39) SMN1; SMN2HTTALDH1A1GAAMAPT
SCHEMBL6828468 0.66 HPGD (0.57) MAPK1HTTATML3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0527186-A4 UNIV ILLINOIS (US) 1995-01-18 EP disclosed
EP-0527186-A1 PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS The Board of Trustees for the University of Illinois (US) 1993-02-17 EP disclosed
WO-1991016820-A1 PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 1991-11-14 WO disclosed