Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 19/20 | 0.91 |
| ▸ | PPP3CA | Q08209 | 2/20 | 0.89 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | THRB | P10828 | 1/20 | 0.79 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709945 | 0.96 | FKBP1A (0.84) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9110110 | 0.95 | FKBP1A (1.00) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9110569 | 0.94 | FKBP1A (1.00) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9109047 | 0.93 | FKBP1A (1.00) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9108260 | 0.93 | FKBP1A (0.89) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9112300 | 0.93 | FKBP1A (0.79) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL9573936 | 0.92 | FKBP1A (0.78) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL16907148 | 0.92 | FKBP1A (0.88) | FKBP1APPP3CAMEN1LMNAMAPT | |
| SCHEMBL1387194 | 0.91 | FKBP1A (0.87) | FKBP1APPP3CA | |
| SCHEMBL9109914 | 0.90 | FKBP1A (0.90) | FKBP1APPP3CAMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515071-A2 | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity | MERCK & CO. INC. (US) | 1992-11-25 | — | — | EP | claimed |
| WO-1995009857-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |
| EP-0515071-A2 | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity | MERCK & CO. INC. (US) | 1992-11-25 | — | — | EP | disclosed |