Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 3/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.53 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.52 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9110298 | 1.00 | CYP3A4 (0.62) | CYP3A4RAB9AMAPTNPC1MAPK1 | |
| SCHEMBL9316110 | 0.85 | APP (0.47) | CYP3A4RAB9AMAPTNPC1CASP3 | |
| SCHEMBL6070869 | 0.84 | MAPT (0.58) | CYP3A4RAB9AMAPTNPC1MAPK1 | |
| SCHEMBL6070874 | 0.84 | MAPT (0.58) | CYP3A4RAB9AMAPTNPC1MAPK1 | |
| SCHEMBL10498631 | 0.83 | MAPT (0.51) | CYP3A4RAB9AMAPTNPC1MAPK1 | |
| SCHEMBL9316714 | 0.83 | CYP2A6 (0.51) | CYP3A4RAB9AMAPTNPC1CASP3 | |
| SCHEMBL9315711 | 0.83 | ALDH1A1 (0.47) | CYP3A4RAB9AMAPTNPC1CASP3 | |
| SCHEMBL9315954 | 0.83 | APP (0.47) | CYP3A4RAB9AMAPTNPC1CASP3 | |
| SCHEMBL9316142 | 0.83 | CA12 (0.48) | CYP3A4RAB9ANPC1CASP3SENP7 | |
| SCHEMBL9316719 | 0.81 | CYP3A4 (0.43) | CYP3A4RAB9ANPC1CASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670831-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995009159-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-04-06 | — | — | WO | disclosed |