Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 18/20 | 0.83 |
| ▸ | FKBP4 | Q02790 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.70 |
| ▸ | PPP3CA | Q08209 | 2/20 | 0.69 |
| ▸ | MLNR | O43193 | 1/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.69 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.69 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.69 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780271 | 0.99 | FKBP1A (0.84) | FKBP1AFKBP4MEN1LMNAMAPT | |
| SCHEMBL9112929 | 0.96 | FKBP1A (0.88) | FKBP1AFKBP4MEN1LMNAMAPT | |
| SCHEMBL9093672 | 0.96 | FKBP1A (0.90) | FKBP1AFKBP4MEN1LMNAMAPT | |
| SCHEMBL9709976 | 0.95 | FKBP1A (0.79) | FKBP1AFKBP4MEN1LMNAMAPT | |
| SCHEMBL9709826 | 0.95 | FKBP1A (0.81) | FKBP1AFKBP4MEN1LMNAMAPT | |
| SCHEMBL8780264 | 0.94 | FKBP1A (0.85) | FKBP1AFKBP4MEN1LMNAMAPT | |
| SCHEMBL9092821 | 0.94 | FKBP1A (0.76) | FKBP1AFKBP4MEN1LMNAMAPT | |
| SCHEMBL9709662 | 0.94 | FKBP1A (0.79) | FKBP1AFKBP4MEN1LMNAMAPT | |
| SCHEMBL1387319 | 0.94 | FKBP1A (0.74) | FKBP1APPP3CA | |
| SCHEMBL9110243 | 0.93 | FKBP1A (0.85) | FKBP1AFKBP4MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995009857-A1 | O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY | MERCK & CO., INC. (US) | 1995-04-13 | — | — | WO | disclosed |
| WO-1993005059-A1 | IMIDAZOLIDYL MACROLIDES | MERCK & CO., INC. (US) | 1993-03-18 | — | — | WO | disclosed |
| EP-0515071-A2 | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity | MERCK & CO. INC. (US) | 1992-11-25 | — | — | EP | disclosed |