Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KYNU | Q16719 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9112414 | 0.86 | LMNA (0.56) | LMNASMN1; SMN2HSD17B10HTTKYNU | |
| SCHEMBL13537619 | 0.85 | LMNA (0.55) | LMNASMN1; SMN2HSD17B10HTT | |
| SCHEMBL11173083 | 0.84 | LMNA (0.58) | LMNASMN1; SMN2HSD17B10HTT | |
| (Benzyloxycarbonylamino)Methylphosphonic Acid SCHEMBL5586441 | 0.84 | LMNA (0.61) | LMNASMN1; SMN2HSD17B10HTT | |
| SCHEMBL13537615 | 0.84 | ELANE (0.55) | LMNASMN1; SMN2HSD17B10HTT | |
| SCHEMBL13537616 | 0.83 | LMNA (0.59) | LMNASMN1; SMN2HSD17B10HTT | |
| SCHEMBL5076531 | 0.83 | HSD17B10 (0.53) | LMNASMN1; SMN2HSD17B10KYNU | |
| SCHEMBL14525450 | 0.81 | SLC6A2 (0.55) | LMNASMN1; SMN2HSD17B10HTT | |
| SCHEMBL18669984 | 0.80 | LMNA (0.56) | LMNASMN1; SMN2HSD17B10HTT | |
| SCHEMBL5063193 | 0.78 | LMNA (0.77) | LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5359115-A | Reacting phosphonic monoester with dialkylazodicarboxylate, triphenylphosphine and secondary alcohol to form diester, hydrolyzing selective ester to form monoester, coupling an aminoacid to yield peptidylphosphonate | AFFYMAX TECHNOLOGIES, N.V. (US) | 1994-10-25 | — | — | US | claimed |
| EP-0659188-A4 | METHODS FOR THE SYNTHESIS OF PHOSPHONATE ESTERS. | AFFYMAX TECH NV (AN) | 1995-11-22 | — | — | EP | disclosed |
| EP-0659188-A1 | METHODS FOR THE SYNTHESIS OF PHOSPHONATE ESTERS | AFFYMAX TECHNOLOGIES N.V. (AN) | 1995-06-28 | — | — | EP | disclosed |
| US-5420328-A | Esterification with alcohol and hydrolysis | AFFYMAX TECHNOLOGIES, N.V. (AN) | 1995-05-30 | — | — | US | disclosed |
| US-5359115-A | Reacting phosphonic monoester with dialkylazodicarboxylate, triphenylphosphine and secondary alcohol to form diester, hydrolyzing selective ester to form monoester, coupling an aminoacid to yield peptidylphosphonate | AFFYMAX TECHNOLOGIES, N.V. (US) | 1994-10-25 | — | — | US | disclosed |
| WO-1994006808-A1 | METHODS FOR THE SYNTHESIS OF PHOSPHONATE ESTERS | AFFYMAX TECHNOLOGIES N.V. (AN) | 1994-03-31 | — | — | WO | disclosed |